(Replying to PARENT post)
"Hydroxychloroquine has not been associated with significant serum enzyme elevations during therapy of rheumatologic diseases. Furthermore, clinically apparent liver injury from hydroxychloroquine is rare. " https://www.ncbi.nlm.nih.gov/books/NBK548738/
"Despite use for more than 50 years, chloroquine has rarely been linked to serum aminotransferase elevations or to clinically apparent acute liver injury."https://www.ncbi.nlm.nih.gov/books/NBK548224/
(Replying to PARENT post)
(Replying to PARENT post)
For those not understanding the jargon (like myself).
(Replying to PARENT post)
I hear beer and wine are hepatotoxic too.
That's why I take milk thistle (silymarin).
I assume the Koreans are all taking silymarin with their chloroquine, which is why they aren't dying en masse from liver failure, right?
(Replying to PARENT post)
Also, for those considering to use the Cinchona bark itself as a prophylactic measure, as a natural / herbal / ayurvedic remedy, note that it also has potentially risky side-effects like slowing the heart, constipation and impact on the nervous system. In large quantity cinchona is UNSAFE and can be deadly. Symptoms of overdose include ringing of the ears, headache, nausea, diarrhea, and vision disturbances. Cinchona can also cause bleeding and allergic reactions, including hives and fever. It also interacts with a lot of other medicines like anti-coagulants, heart medicines, antacids etc. Be sure to check your medication list first.
(Replying to PARENT post)
(Replying to PARENT post)
2. it's already available for compassionate use.
The FDA is allowing chloroquine and remdesivir to be used for 'compassionate use' to treat the coronavirus.
https://www.businessinsider.com/chloroquine-remdesivir-compa...
(Replying to PARENT post)
The FDA's Office of new drugs is split into divisions (dermatology, oncology etc) and the different divisions have different approval criteria as you mention. From my Onco friends' PoV, cancer patients are pretty much assumed to be dying anyway so the standard of risk is quite different from, say, Derm, whose patients don't really die of anything except cancers.
Note: I have presented to the FDA and have written clinical trial requests (e.g. IND) which have been approved, but I have never done a submission to OOD. However my friends who do really talk about the approval path in a different way than I used to.
Don't self-medicate with chloroquine. It's very hepatotoxic.