> In particular, how easy will distribution be, considering that HIV is extremely easily preventable but it still spreads, because of lack of distribution of knowledge, I assume.

This is a huge problem in the US. Truvada must be taken everyday to prevent HIV, and in 2015, it cost $1400 for a 30 day supply. In 2021, it costs between $1900 and $2500+ for a 30 day supply in the US.

Elsewhere in the world, Truvada might cost $40. In Australia, Truvada costs $8 for a 30 day supply[1].

The only other drug approved for PrEP in the US is Descovy, which is manufactured by Gilead, too, and costs $2300+ minimum for a 30 day supply.

[1] https://www.independent.co.uk/news/world/americas/us-politic...

H.i.v. spread is not so easy to prævent as many think.

Many seem to think that the use of a condom turns transmission risk from 99% to 0% or something along those lines.

The reality is more so that it changes 1% to 0.3%, and it heavily depends on the sex act and direction of transmission as well.

Another not so often sung fact is that the transmission rate from patients who take blockers properly, and thus have an undetectable viral load is 0%.

https://www.aidsmap.com/about-hiv/estimated-hiv-risk-exposur...

Cost is the largest factor. HIV could be nearly eliminated entirely if PREP wasn’t a cash cow for Gilead.

15,000 people a year still die in the US with HIV.

https://www.hiv.gov/hiv-basics/overview/data-and-trends/stat...

Distribution? There’s no evidence that it works yet

This vaccine doesn't prevent infection by HIV so it's not ready for real world use. What it does is prime the immune system so that a second vaccine might become more effective. The second vaccine still needs to be developed though