Rutin is basically an antioxidant that contains quercetin. Yet another antioxidant which “prolongs” lifespan by a negligible percentage compared to other antioxidants and mice on a keto diet which avoid the oxidative stress from carbs in the first place.

It seems we always hit a limit to lifespan studies. Unless we are able to modify the organs themselves, including the insulin response and mTOR, no single substance will ever prolong lifespan in a significant way.

This says one of the highest natural sources is from olives. Association with Mediterranean diet maybe? Anyway this is linked to quercetin and other citrus bioflavonoids supplements. Pretty sure selegiline still knocks this out of the park though.

We should investigate the benefits of sodium as well. Sodium is vitally important for many bodily function and is a very misunderstood nutrient.

Historically people consumed much more salt, and don't give me the "people used to die when they were 35" nonsense. There is a big difference between being kicked by a horse vs dying of a stroke.

Diet/longevity studies in mice aren't good sources of information for the general population. They are (at best) pilots/guides for further (more expensive) human testing.

Unless it's a treatment for an acute condition that you suffer from, and there's some logical basis for trusting the effect will equally apply to humans, there's no point in basing personal dietary behavior in any way off of such studies. And a lesser point is that there is likely enough agreed upon research in this area that you are not adhering to already! (Myself included, though I do try)

Of course, the people who might work on such trials might frequent HN, and research is just intrinsically interesting, so I'm not saying "this is a bad post".

I will offer anyone 100-1 odds that sodium rutin will not be approved by the FDA for human anti-aging purposes in the next 20 years.

Interesting result but needs confirmation in other studies, particularly as the rutin formulation seems to be homegrown by the research team.

Incidentally, I recently learned about the Interventions Testing Program [1,2]. This is an ongoing very well conducted study investigating different drugs and supplements for longevity extension in mice. Aside from being highly rigorous, reproducible and free of conflicts, the results of this are fascinating. Particularly striking is the benefit of drugs which reduce peak glycemia after meals (acarbose and canagliflozin) in male mice.

[1] https://www.nia.nih.gov/research/dab/interventions-testing-p...

[2] https://peterattiamd.com/richardmiller/

Only 8% of experiments on mice work on humans… friendly reminder.

Perhaps it's part of their natural diet, and not part of the typical "lab diet".

I believe there are a whole slew of diet modifications that are believed to increase lifespan in humans >10%.

Doesn't make people eat that diet...

1. The abstract is not great.

2. This is a study from China, including "School of Traditional Chinese Medicine"

How do you measure "health" in percent? I don't think the article quantified that.

What is sodium rutin? I know about rutin but never heard about sodium rutin.

Headline is wrong. Only lifespan did extend by 10%. Not both.

Great news for aging rodents all around the world! Too bad most experiments that work on mice have no or negative effects on humans, so we probably won't be able to benefit from this.

Tangential: I think it should be "we investigate" instead of "we investigating" in the first paragraph of the abstract? How can such an awful mistaken use of grammar pass peer-review and other processes that precede publishing? Or am I the one who is mistaken?

EDIT: this is an "early view" of the paper, before it gets published. No idea about the implications of that.

Both Fullerene C60 and SkQ1 can double lifespan in mice. Everybody should take (at his own risk) SkQ1, it's gonna create a new generation of temporally old but physically young people. SKQ1 being considered non toxic and properly eliminated by the body and given it's large (>150 studies) body of evidence showing revolutionar anti ageing (totally prevent Alzeihmer, Parkinson), to me the risk/benefit cost is a no brainer.

In addition to it, mexidol can be a nice augmentation. Of course it's only a part of the complete anti ageing solution, see also:

https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ http://geroprotectors.org