(Replying to PARENT post)
Money is absolutely an object. People are starting to do trials of early detection from circulating tumor DNA, and finding that the hit rate is alarmingly high. A decent portion of the population has some kind of malignancy, but most of these will either be cleared by the immune system, or be completely benign. Another problem is, if we detect this tumor DNA, it doesn't tell us where in the body the tumor might be. So then you're talking massive workups including while body CT scans and such for a problem that isn't going to be a problem for 99% of people. I'm not joking when I say that if rolled out as is, this has the potential to bankrupt the entire healthcare system with unnecessary procedures.
To be clear, I very much think that early detection of tumors will someday be an essential part of cancer treatment. We are not there yet.
π€chrisamillerπ3yπΌ0π¨οΈ0
(Replying to PARENT post)
problems:
- False-positive results
- False-negative results
"Mammograms are the best breast cancer screening tests we have at this time. But mammograms have their limits. For example, they arenβt 100% accurate in showing if a woman has breast cancer. They can miss some cancers, and sometimes they find things that turn out not to be cancer (but that still need further testing to be sure)."
https://www.cancer.org/cancer/breast-cancer/screening-tests-...
π€pellaπ3yπΌ0π¨οΈ0
(Replying to PARENT post)
Look at GRAIL therapeutics. Cancer sheds DNA that can be detected and amplified. We use this sometimes to try to tell if someone will have a recurrence before scans actually show it.
Sequencing is hard, and there are contaminants and difficulties calling a mutation/sequence cancerous, but I have had patients self-refer after a positive GRAIL test, no symptoms, and bam, biopsy from area of interest shows early cancer.
π€sam537π3yπΌ0π¨οΈ0
(Replying to PARENT post)
You can detect tumor cells circulating in blood for certain cancers. You can get the cost down by having these tests covered at regular intervals by insurance companies.
π€asdffπ3yπΌ0π¨οΈ0
(Replying to PARENT post)
Whats the best way to detect cancer (money is no object) and how do we get that cost down 10x and get everyone to participate?