(Replying to PARENT post)

I do not understand the whole "paracetamol/acetaminophen is useless and dangerous". It is dangerous if you overdose, but in normal doses it is as harmless as it can go, and while it may be indeed in issue when people are not as well educated in how to use it, judging a drug by the effects of what happens if you overdose would rule out a lot of other drugs and substances.

About its effectiveness, it is more useful in some cases and less in others, in principle if inflammation is part of the problem NSAIDs will work much better, but in many cases they are both effective in comparable degrees. It all depends on the source of pain. Personally I take NSAIDs only if it is really needed, because in the past they have really messed up my stomach. And the cases that NSAIDs were effective and paracetamol was not was in some injury cases.

And yeah, there are studies that show paracetamol is effective and others that show it is ineffective, it all has to do with the exact cause of the symptoms because "pain" and "fever" are too general as symptoms. The fact that it does not work in some case does not mean it does not work in another and it is useless.

πŸ‘€freehorseπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

I had outpatient surgery about ten years ago.

I was to alternate between prescription strength Tylenol and Ibuprofen. It was then that I discovered that Tylenol seemed to do very little if not nothing at all for me. I would be in horrible pain for the couple hours I'd be on Tylenol and in mild discomfort durring the Ibuprofen's reign.

My dad outright refuses to use tylenol because he swears it makes him anxious and angry. I have never encountered this.

My wife uses Tylenol regularly and says it works great for her, just as well as other painkillers.

I am not a doctor nor a scientist and my sample size is meaningless - yet I suspect it's efficacy varies by person.

πŸ‘€donatjπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

Just so you know who is funding this site: https://en.wikipedia.org/wiki/American_Council_on_Science_an...
πŸ‘€itamarstπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

I've never understood why people even bother with paracetamol/acetaminophen. Ibuprofen and other NSAIDs like naproxen are (in my experience) much better painkillers and are much less likely to kill you.

Edit: NSAIDs are bad if you are bleeding (or are about to be bleeding like before surgery), and they can cause stomach ulcers.

πŸ‘€noodlesUKπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

no different than Phenylephrine. An almost useless chemical sold as a nasal decongestant all over the US.
πŸ‘€sidewndr46πŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

There was a discovery that acetaminophen plus ibuprofen produce a synergistic effect similar to opioids. [0] This combination stresses the liver, stomach lining (without famotidine), and kidneys so it's not something to use chronically. It was even OTC productized as "Advil Dual Action". [1]

0. https://pubmed.ncbi.nlm.nih.gov/20142348/

1. https://www.ada.org/publications/ada-news/2020/march/fda-app...

πŸ‘€sacnoradhqπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

I really don't understand why NSAID Celecoxib is not available over the counter. It is a Cox2 selective inhibitor which reduces the stomach issues, and from studies I've seen the myocardia issues are within comparable ranges to acetaminophen.
πŸ‘€gueloπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

Triflusal was approved in Europe as lone prophylaxis for stroke. It has better characteristics than low-dose aspirin for MI except for [help me remember the reason it was dismissed by US medical establishment].

https://pubmed.ncbi.nlm.nih.gov/29866011/

https://ichgcp.net/clinical-trials-registry/NCT02616497

πŸ‘€sacnoradhqπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

Interesting link. I've never experienced significant headache relief from acetaminophen/Tylenol, and it's nice to see some peer-reviewed results replicating my experience.
πŸ‘€mturmonπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

As someone who is allergic to NSAIDs and who gets no relief from Tylenol, it's really apparent the lack of effective OTC painkiller options.

When I herniated a disc in my lower back, the ER doctor was very very hesitant to give me an opioid even though I was in constant, excruciating pain. But if you're allergic there's basically no other options out there.

πŸ‘€brooke2kπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

This is a terrible post.

The JNJ drug is "comparable" but with less toxicity. That's great!

But the author then goes on some weird tangent saying "well, acetaminophen isn't that great of a pain reliever anyways".

Ok, but the goal wasn't a better analgesic, just a safer one?

πŸ‘€refurbπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

(2022)

This is the first time I have read that Tylenol is of questionable efficacy. I haven't done any self-study of it, I tend to take one of the other NSAIDs. I have a bottle of ibroprofen at the moment, but Naproxen Sodium is usually my go-to.

πŸ‘€unethical_banπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

You can already make acetaminophen nontoxic by pairing it with N-Acetyl Cysteine, which is available commercially as a supplement.
πŸ‘€ScaevolusπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

Sounds like the β€œnew” useless Sudafed
πŸ‘€onewheeltomπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0

(Replying to PARENT post)

These OTC drugs biggest scam I have seen. $10 for a box of bills that does not work that well. At best these are placebos, at worse they are dangerous because people take too much of them owing to their infectiveness.
πŸ‘€paulpauperπŸ•‘2yπŸ”Ό0πŸ—¨οΈ0