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I was to alternate between prescription strength Tylenol and Ibuprofen. It was then that I discovered that Tylenol seemed to do very little if not nothing at all for me. I would be in horrible pain for the couple hours I'd be on Tylenol and in mild discomfort durring the Ibuprofen's reign.
My dad outright refuses to use tylenol because he swears it makes him anxious and angry. I have never encountered this.
My wife uses Tylenol regularly and says it works great for her, just as well as other painkillers.
I am not a doctor nor a scientist and my sample size is meaningless - yet I suspect it's efficacy varies by person.
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Edit: NSAIDs are bad if you are bleeding (or are about to be bleeding like before surgery), and they can cause stomach ulcers.
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0. https://pubmed.ncbi.nlm.nih.gov/20142348/
1. https://www.ada.org/publications/ada-news/2020/march/fda-app...
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When I herniated a disc in my lower back, the ER doctor was very very hesitant to give me an opioid even though I was in constant, excruciating pain. But if you're allergic there's basically no other options out there.
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The JNJ drug is "comparable" but with less toxicity. That's great!
But the author then goes on some weird tangent saying "well, acetaminophen isn't that great of a pain reliever anyways".
Ok, but the goal wasn't a better analgesic, just a safer one?
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This is the first time I have read that Tylenol is of questionable efficacy. I haven't done any self-study of it, I tend to take one of the other NSAIDs. I have a bottle of ibroprofen at the moment, but Naproxen Sodium is usually my go-to.
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About its effectiveness, it is more useful in some cases and less in others, in principle if inflammation is part of the problem NSAIDs will work much better, but in many cases they are both effective in comparable degrees. It all depends on the source of pain. Personally I take NSAIDs only if it is really needed, because in the past they have really messed up my stomach. And the cases that NSAIDs were effective and paracetamol was not was in some injury cases.
And yeah, there are studies that show paracetamol is effective and others that show it is ineffective, it all has to do with the exact cause of the symptoms because "pain" and "fever" are too general as symptoms. The fact that it does not work in some case does not mean it does not work in another and it is useless.