(Replying to PARENT post)

I remember reading (probably from one of his books) that Sagan's idea for a life-detecting experiment on Mars was never actually sent there (apparently this experiment went instead). IIRC, it was basically to put a sample in a box and just watch it to see if anything changed at all in a way that indicates that some chemical process is happening.

Here are some interesting slides I found while trying to figure out what his actual experiment idea involved: https://www.vanderbilt.edu/olli/archive/Life_On_Mars_Session...

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(Replying to PARENT post)

Microscopy could also be a good route. Microbial life should look pretty distinct from inorganic matter, even if everything in the soil sample were dead by the time it was imaged. As far as I know, we have not sent a microscope up capable of resolving even a large mammalian cell, let alone resolve 1 micron bacteria (if these microbes are even to be similar in size as those on Earth). I suspect the vibrations during launch make it especially challenging to actually get a powerful microscope out to Mars unharmed.
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