I think the biggest impact of virtual threads is that the ecosystem will abandon asynchronous APIs. No more futures, callbacks, servers where you have to make sure not to block the thread, reactive frameworks, etc. Just nice simple imperative blocking code. Nima is the first example i've seen:

https://helidon.io/nima

We've had two production bugs in the last two weeks caused by handlers blocking the server thread in apps using an async web framework, which would simply not have happened with a synchronous server.